ABSTRACT
Covid-19 is a viral disease that affects humans caused by a type of virus belonging to the family Coronaviridae called the SARS-CoV-2 virus. The parasitic infection associated with this disease affects the host's immune response regulation. The levels of IgG and IgM of Toxoplasma gondii in the serum of patients with COVID-19 were measured by immunoassay of the patient's sera by ELISA. Also, the level of interferon-gamma (IFN-gamma) in a covid-19 patient with or without Toxoplasmosis was evaluated. 120 samples were collected, 60 were positive for COVID-19, confirmed by clinically and radiographic examination, and 30 were in the control group. The results showed a significant difference between the infection with Covid-19 and T. gondii during the chronic phase of Toxoplasmosis compared to the negative relationship in the acute phase. The results of INF-gamma levels among Covid-19 patients were positive for all samples included in the test (30 Covid-19 patients and 30 patients COVID-19(+)/T. gondii IgG) compared to the control group. The chronic form of Toxoplasma disease, due to change in the production of this interferon, the COVID-19 infection has changed.Copyright © 2023 by Razi Vaccine & Serum Research Institute.